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KMID : 0371619870030010063
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Journal of Wonkwang Medical Science
1987 Volume.3 No. 1 p.63 ~ p.73
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A Study on Autonomic Dysfunction in Schizophrenics taking antipsychotics
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Abstract
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The study was to investigate autonomic dysfunction using autonomic function tests in schizophrenics taking antipsychotics over 30 days. This study was also conducted to know whether quantification of the autonomic dysfunction in schizophrenics taking antipsychotics was possible. 30 people were participated for a control group and 45 schizophrenics taking antipsychotics over 30 days were participated for an experimental group.
The results were as follows :
1) 30/15 ratio on standing in schizophrenics was more decreased than in controls and was appeared to be abnormal. It showed a significant difference between the two groups (P ( 0.001).
2) Valsalva ratio in schizophrenics was more decreased than in controls and was appeared to be abnormal. It showed a significant difference tetween the two groups (P ( 0.151).
3) E? I ratio in schizophrenics was more decreased than in controls. It showed a significant difference between the two groups (P ( 0.000). Although the E?I ratio was within the normal range in controls and schizophrenics.
4) Blood pressor rise on cold pressor test didn´t showsignificant differeace between the two groups and was also within the normal range.
From the results, it was concluded that there was a parasympathetic dysfunction. But no sympathetic dysfunction in schizophrenics. Also the autonomic dysfunction in schizophrenics taking antipsychotics were measured quantitatively using 30/15 ratio on standing, Valsalva ratio, E?I ratio and blood pressure rise on cold pressor test, therefore it suggested that quantification of the autonomic dysfunction was possible in schizophrenics taking antipsychotics.
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